剑桥导游太阳系

本书以最新的视角描述了行星和月亮。开始用短短的篇幅介绍行星的观测和发现历史，然后介绍行星及其卫星的共同特点、演化过程和状况。在各章节中讲述各个行星和太阳系其它天体，包括新近的多种空间任务，从阿波罗探月到近期的木星和火星探测。书中充满了至关重要的事实和信息，以及极其精美的彩色照片。     

老师想开点 学生自觉点

我真不明白,英语老师是一位很开明的人,干什么留那么多家庭作业。一想到英语作业,我心里那叫一个烦!烦得我把三九天当三伏天,吃冰棍降温。再一想到不及格的物理,我真有种穿上裙子去南极的冲动。我真纳闷!我的不明白,为什么物理作业我就懒得动呢?我心里怎么就一个说不出的一个“烦”字?本来好好的假期,本来好好的新年,本来好好的我,就让这N堆的作业给搅了呢!得啦!老师您不仁,那也别怪我不义了。音乐起,练习册来,答案翻,笔开抄。我心里那叫一个爽!抄完了,看着我那本被干掉的练习册,我心里特别的难受。堂堂一位市级三好生,好好一位优秀干部,乖…     

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

Systematic genetic interaction studies have illuminated many cellular processes. Here we quantitatively examine genetic interactions among 26 Saccharomyces cerevisiae genes conferring resistance to the DNA-damaging agent methyl methanesulfonate (MMS), as determined by chemogenomic fitness profiling of pooled deletion strains. We constructed 650 double-deletion strains, corresponding to all pairings of these 26 deletions. The fitness of single- and double-deletion strains were measured in the presence and absence of MMS. Genetic interactions were defined by combining principles from both statistical and classical genetics. The resulting network predicts that the Mph1 helicase has a role in resolving homologous recombination-derived DNA intermediates that is similar to (but distinct from) that of the Sgs1 helicase. Our results emphasize the utility of small molecules and multifactorial deletion mutants in uncovering functional relationships and pathway order.     

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.     

计算机联锁

本文探讨了计算机联锁系统的安全.